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程亮教授课题组在Angew. Chem. Int. Edit.上发表论文
发布时间:2022-09-15 点击:10

题目:

HXV2O5 Nanocatalysts Combined with Ultrasound for Triple Amplification of Oxidative Stress to Enhance Cancer Catalytic Therapy

作者:

Linqian Hou, Fei Gong*, Zhihui Han, Yuanjie Wang, Yuqi Yang, Shuning Cheng, Nailin Yang, Zhuang Liu, and Liang Cheng*

单位:

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Lab Carbon Based Functional Materials and Devices, Soochow UniversitySuzhou, 215123, Jiangsu (China)

摘要:

Multiple amplification of tumor oxidative stress has been demonstrated as efficient strategy to enhance the reactive oxygen species (ROS)-mediated cancer therapy. Herein, vanadium-based nanocatalysts, hydrogen vanadium bronzes (HXV2O5, for short HVO), were constructed and employed as novel biocatalysts for amplifying tumor oxidative stress and enhancing cancer catalytic therapy. Such HVO nanocatalysts harboring multivalent V element possessed multi-functional catalytic activity in decomposing H2O2 into ·OH and depleting endogenous glutathione (GSH) to dually amplify tumor oxidative stress. Meanwhile, HVO nanocatalysts could also be activated by ultrasound to further triply amplify oxidative stress. The massive intracellular ROS caused mitochondrial dysfunction, DNA damage, cell cycle arrest, and cell proliferation inhibition, further realizing cancer cell death and tumor growth inhibition. Collectively, HVO nanocatalysts highlight the remarkable value of ROS-mediated cancer therapies.

影响因子:

15.336

分区情况:

一区

链接:

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202208849

 

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